Efficacy and Safety of Radiofrequency Renal Denervation in Drug Resistant Hypertension

Inclusion Criteria: * Age ≥ 18 and ≤ 80 years at time of randomization * Informed consent * Treatment with full doses of 3 or more anti-hypertensive medications of different classes, of which one is a diuretic. * Office Systolic BP (SBP) ≥ 160 mmHg or Diastolic BP (DBP) ≥ 100 mmHg Exclusion Criteria: * An estimated glomerular filtration rate (eGFR) of \< 30 mL/min/1.73 m2 * Ambulatory Blood Pressure Monitoring (ABPM) 24 hour average SBP \< 135 mmHg or DBP \< 85 mmHg * Symptomatic(secondary) hypertension * Severe renal artery stenosis or renal arteries abnormalities * Individual is pregnant, nursing or planning to be pregnant * Severe hepatic dysfunction * Any other clinically important renal, hematological, metabolic, neurological, gastrointestinal, hepatic or pulmonary disorders or dysfunctions preventing study participation (investigator's assessment)