Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies

Inclusion Criteria: * Patients with the following diseases: * Acute myeloid or lymphocytic leukemia in first remission at standard or high-risk for recurrence. * Acute leukemia in greater than or equal to second remission, or with early relapse, or partial remission. * Chronic myelogenous leukemia in accelerated phase or blast-crisis. * Chronic myelogenous leukemia in chronic phase * Recurrent or refractory malignant lymphoma or Hodgkin's disease * Multiple myeloma. * Chronic lymphocytic leukemia, relapsed or with poor prognostic features. * Myeloproliferative disorder (polycythemia vera, myelofibrosis) with poor prognostic features. * Severe aplastic anemia after failure of immunosuppressive therapy. * Age 10-65 years. * Zubrod performance status less than or equal to 2. * Adequate cardiac and pulmonary function. Patients with decreased LVEF \< 40% or DLCO \< 50% of predicted will be evaluated by cardiology or pulmonary prior to enrollment on this protocol. * Patient or guardian able to sign informed consent. Exclusion Criteria: * Life expectancy is severely limited by concomitant illness. * Serum creatinine greater than 1.5 mg/dL or Creatinine Clearance less than 50 ml/min . * Serum bilirubin greater than or equal to 2.0 mg/dl, SGPT greater than 3 x upper limit of normal * Evidence of chronic active hepatitis or cirrhosis * HIV-positive * Patient is pregnant