UnknownPhase 4

Duration of Antibiotic Therapy in Community - Acquired Pneumonia

Italy892 participantsStarted 2012-01

Plain-language summary

The purpose of the study is to assess the efficacy of an individualized approach to duration of antibiotic therapy based on each subject's clinical response compared to a local standard approach in patients coming from the community and who are hospitalized because of a pneumonia.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Diagnosis of pneumonia:
✓. An appropriate empiric antibiotic therapy for the pneumonia received within 24 hours after admission to the hospital.
✓. A clinical stability reached within 5 days after hospital admission, in the absence of any changes of the initial empiric antibiotic therapy.
✓. Signed informed consent

Exclusion criteria

✕. Patients with immunodeficiency, defined as: chemotherapy in the previous 12 months, radiotherapy in the previous 12 months, transplantation, immunosuppressive treatment, hematologic malignancy, AIDS or HIV with CD4 count \< 200, asplenia.
✕. Patients with a concomitant infection on admission to the hospital requiring antibiotic therapy (i.e urinary tract infection). The presence of sepsis due to pneumonia will not be considered another concomitant infection.
✕. Patients with documented bacteremia due to S. aureus in a blood culture (both methicillin resistant and susceptible S. aureus)
✕. Patients with etiology of pneumonia due to fungi, mycobacterium or Pneumocystis jiroveci.
✕. Patients hospitalized in the previous 15 days

What they're measuring

Composite outcome including adverse events

Timeframe: 30 days

Trial details

NCT IDNCT01492387

SponsorUniversity of Milan

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-12

Contact for this trial

Stefano Aliberti, MD

00393394171538 stefano.aliberti@unimib.it

View on ClinicalTrials.gov More Pneumonia trials