Evaluation of Oral Lipid Ingestion in Relation to Ovarian Androgen Secretion in Polycystic Ovary Syndrome (PCOS)

General Inclusion Criteria: * Acceptable health based on interview, medical history, physical examination, and lab tests * Ability to comply with the requirements of the study * Ability and willingness to provide signed, witnessed informed consent Inclusion Criteria for PCOS: * Between the ages of 18-40 years * Body mass index between 18 and 25, or between 30 and 40 * Less than or equal to 8 periods annually * An elevated serum androgen level or skin manifestations of androgen excess * Normal thyroid function tests and normal prolactin level * Exclusion of late-onset adrenal hyperplasia Inclusion Criteria for Ovulatory Controls: * Between the ages of 18-40 years * Body mass index between 18 and 25, or between 30 and 40 * Normal regular monthly periods * No clinical evidence of androgen excess * No evidence of polycystic ovaries on ultrasound Exclusion Criteria: * Diabetes mellitus * Clinically significant pulmonary, cardiac ,renal, hepatic, neurologic, psychiatric, infectious, and malignant disease * High blood pressure * Current or recent (within 6 weeks prior to study entry) injection of any drugs known or suspected to affect reproductive function including oral contraceptives, metformin, thiazolidinediones, glucocorticoids, GnRH-agonists, or anti-androgens (spironolactone, flutamide, etc) * Documented or suspected history of use of recent (within one year) illicit drug abuse or alcoholism * Tobacco smoking if salsalate or PCE will be administered * Ingestion of any …