Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection… (NCT01481402) | Clinical Trial Compass
CompletedNot Applicable
Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)
Denmark21 participantsStarted 2011-07
Plain-language summary
Purpose: The purpose of the study is to examine if treatment with liothyronine increases left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with stable, chronic systolic heart failure
* T3 ≤1.4 nmol/l in two blood samples, TSH is to be normal
* LVEF ≤ 45 % on prior echocardiography
Exclusion Criteria:
* Established thyroid illness
* Atrial fibrillation/flutter
* More than 20% ventricular extrasystoles
* Severe chronic obstructive lung disorder
* Pregnancy. Pregnancy testing will be done for fertile women
* Age \< 18 years
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial looked at using liothyronine — a thyroid hormone — in heart failure patients who also have low T3 syndrome; could you check whether I have low T3 syndrome, and if so, does that change how you'd think about my heart failure treatment?
2The trial measured left ventricular ejection fraction as its main outcome — can you tell me what my current LVEF is, and help me understand whether improving it with a thyroid hormone like liothyronine is something worth exploring in my case?
3Since this trial is listed as Phase NA and has already completed, what do you know about what the results showed, and does the evidence look strong enough to consider liothyronine as part of my care or is it still too early to draw conclusions?
4Liothyronine is a hormone that affects heart rate and metabolism — what are the risks of adding it for someone with my specific heart condition, especially if my heart is already under stress?
5Are there standard heart failure treatments I should try first before considering something like this, or do you think the low T3 angle makes this worth discussing sooner in my treatment plan?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.