A Study to Investigate the Effect of SB-705498 on Chronic Cough

Inclusion Criteria: * Male or female between 30 -75 (Part A) and 18-75 (Part B) years of age inclusive. * Non-child bearing women or women of child bearing potential if they agree to use contraception as indicated by the protocol * Non-smoker for at least 6 months with a pack history \<5 pack years (Pack years = (No. of cigarettes smoked/day/20) x No. of years smoked). * Body weight \> 50 kg and body mass index (BMI) within the range 19 - 30.0 kg/m2 (inclusive). * Capable of giving written informed consent. * Agree to use contraception listed as acceptable * Normal 12-lead ECG at screening. * Chronic cough (Part B only) * Good general health, apart from chronic cough (part B only), as determined by a responsible physician. Exclusion Criteria: * A history of gastrointestinal, hepatic, renal or multiple cardiovascular risk factors. * Positive pre-study drug/alcohol screen. * Positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening. * A positive test for human immunodeficiency virus (HIV) antibody (if determined by the local standard operating procedures (SOPs)). * History of regular alcohol consumption within 6 months of the study. * Exposure to more than four new chemical entities within 12 months prior to the start of the study. * Participation in a clinical trial with a new molecule entity or any other clinical trial within 30 days of the start of the study. * Use of prescription or non-prescription drugs, as well…