Levetiracetam to Prevent Post-Traumatic Epilepsy

Inclusion Criteria: * Acute head injury associated with one of the following: Intracranial hemorrhage, including epidural, subdural and intracerebral hemorrhage or with cerebral contusion(s) of any size; Penetrating (foreign body) head injury; Skull fracture and dural tear; Seizure within 8 hours of head injury * Onset of head injury within 8-hours of proposed treatment initiation. * Glasgow Coma Scale 6-15. Exclusion Criteria: * Clinical contraindications: * Previous epilepsy or status epilepticus. * Any systemic illness or unstable medical condition that might pose additional risk, including: renal insufficiency, other unstable metabolic or endocrine disturbances, and active systemic cancer. * Psychosis within six months of enrollment as determined by history of hospitalization for psychosis or medications for psychosis. * Moderate to severe mental retardation (IQ\< 55 or\>2 school grade levels below the expected for age \[expected age = grade level +5\]). * Clinical/Laboratory Indicators: * Serum creatinine \> 1.5 on the day of treatment initiation for adults. * Serum creatinine ≥1.5 for subjects ≥17 years old, ≥1.0 for subjects 13-17 years old and ≥0.7 for subjects 6-12 years old. * Pregnancy * Use of any CNS-active investigational drugs within 3 months of enrollment. * Use of Antiepileptic Drugs (AEDs) within two months of enrollment, for any indication. * Allergy/sensitivity to study drugs or their formulations: * Active drug or alcohol depe…