Study to Identify the Genetic Variations Associated With Phantom Limb Pain (NCT01462448) | Clinical Trial Compass
CompletedNot Applicable
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
United States726 participantsStarted 2012-03
Plain-language summary
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group. Total RNA will also be isolated and profiled to asses the degree to which our gene(s) of interest are expressed in the presence or absence of phantom limb pain. Some proteins, such as inflammatory antibodies or the neurotrophin brain-derived neurotrophic factor (BDNF), will also be assessed for their association(s) with phantom limb pain.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Chronic PLP Group:
* At least 18 years of age.
* Written informed consent and written authorization for use or release of health and research study information
* Single or multiple upper and/or lower limb amputation
* At least three months post-amputation
* Ability to follow study instructions and likely to complete required visit(s)
* Experienced PLP for at least one month and at least 3 times per week
* Phantom limb pain differentiated from residual limb pain by physical exam.
* Subjects taking blood thinners or other medications that do not increase risk during a blood draw.
Non-Chronic PLP Group:
* At least 18 years of age.
* Written informed consent and written authorization for use or release of health and research study information
* Single or multiple upper and/or lower limb(s) amputation
* At least three months post-amputation
* Ability to follow study instructions and likely to complete required visit(s)
* Experienced PLP less than 10 times total and/or for less than two weeks
* Subjects taking blood thinners or other medications that do not increase risk during a blood draw.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Identification of Unique Single Nucleotides Polymorphisms (SNPs) associated with Phantom Limb Pain (PLP)
Timeframe: 5 years
Trial details
NCT IDNCT01462448
SponsorHenry M. Jackson Foundation for the Advancement of Military Medicine