DaTSCAN Imaging in Aging and Neurodegenerative Disease

Inclusion Criteria: * Diagnosis of one of the syndromes of interest using established criteria * Age 40-90 inclusive * MMSE score above 10 * No active medical disorder that could preclude participation * Stable medication regimen over previous four weeks * Absence of certain medications that could significantly impact the DaTscan findings * For those with dementia, caregiver that is with the patient at least 4 hours/day for at least 5 days per week * For those with dementia, or severe parkinsonism, patient and caregiver willing and able to participate in all study-related procedures * Patient is capable of giving informed consent, or if appropriate, has caregiver capable of giving consent on the subject's behalf. Exclusion Criteria: * Does not fulfill criteria for any of the desired diagnoses * Age \<40 or \>90 * Women with intact uterus and not post-menopausal unless pregnancy test performed at screening is negative * Women who are pregnant or are breast-feeding an infant * MMSE score \<10 * Active medical disorder that could preclude participation in this protocol * Hypersensitivity to the radioligand, cocaine, or iodine (including seafood allergy) * Myocardial infarction or cerebral infarct over preceding year, stable or unstable angina, known symptomatic coronary artery disease * Renal or liver disease viewed by the physician to be too severe to warrant DaTscan infusion/imaging * History of significant alcohol or drug abuse * Any other medical disorder consi…