Efficacy and Safety of Alginos Oral Suspension to Treat Laryngopharyngeal Reflux

Inclusion Criteria: * Patients with age of 12-75 years old (inclusive) * Patients with at least one symptom consistent with LPR, including hoarseness, throat clearing, throat pain, globus sensation in the throat, or chronic cough ≧ 4 weeks before entering study * Patients with a total reflux symptom index (RSI) \>10 (based on a self-administered 9-item questionnaire of voice/throat complaints) * Patients with a total reflux finding score (RFS) \>5 (based on a laryngoscopic examination by investigators) * Patients or their legal representatives have signed the informed consent form Exclusion Criteria: * Patients with viral or bacterial laryngitis, or occupational exposures causing laryngitis * Patients with erosive GERD as evidenced by upper GI endoscopy * Patients with laryngeal or hypopharyngeal cancer, esophageal or gastric cancer, , or with history of neck radiation therapy * Patients with history of uncontrolled hypertension or moderate to severe renal impairment * Patients with history of esophageal or gastric surgery * Patients with active pulmonary infection (pneumonia, tuberculosis) as evidenced by chest X-ray * Patients with endotracheal tube intubation within 2 months before entering study * Patients had taken any alginate preparations within 2 days; H2-blocker, prokinetic agent or antacid within 7 days; or proton pump inhibitors (PPIs) within 14 days before screening * Patients with a history of allergy to the study drugs or their related compounds * Patients wi…