Blinking and Yawning in Epilepsy: The Role of Dopamine (NCT01432821) | Clinical Trial Compass
CompletedNot Applicable
Blinking and Yawning in Epilepsy: The Role of Dopamine
France31 participantsStarted 2011-09
Plain-language summary
The objective of the present study is to assess dopaminergic reactivity with behavioural markers (i.e. yawning and blinking) in patients with idiopathic generalized epilepsy compared to matched healthy controls, after injection of either low dose of apomorphine or placebo.
Other parameters will be recorded: biochemical (prolactin, GH) and neurophysiological (Spike-Waves Discharge: SWD rating). Safety parameters will be recorded to assess tolerance.
Who can participate
Age range18 Years – 40 Years
SexALL
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Inclusion Criteria:
For patients:
* Men and women aged between 18 and 40
* Person affiliated to social security or beneficiary of such a regime
* idiopathic generalized epilepsy treated with lamotrigine, an association of lamotrigine, topiramate, levetiracetam, lamotrigine or levetiracetam alone (group patients) for at least 14 days without changing doses The idiopathic generalized epilepsy is defined by generalized seizures: generalized tonic-clonic seizures, absences or myoclonic seizures, excluding any other type of seizure, and electroencephalographic appearance following: presence of interictal EEG discharge generalized to type of spikes, spike-wave or wave polyspikes generalized, sporadic or rhythmic\> or = 3 Hz background activity is normal.
For healthy volunteers:
* Men and women aged between 18 and 40
* Person affiliated to social security or beneficiary of such a regime
Exclusion Criteria:
* Topic wrongly included
* Deflecting protocol that can skew the primary endpoint
* Primary endpoint missing
* If the investigator considers the health of the subject is incompatible with the continuation of the study.
Criteria for non-inclusion
* For patients:
* The presence of interictal focal discharges on EEG previous
* The emergence of partial seizures
* Restless Leg Syndrome
* All non-antiepileptic treatment may affect levels of dopamine
* Current use of illicit drugs.
* A person deprived of liberty by judicial or administrative person being a measure of…