Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery

Inclusion Criteria: * age ≥ 18 years * signed written consent * symptomatic patients (NYHA-stadium ≥ III) for at least 3 months with an exploited medical heart insufficiency therapy * increased perioperative risk with a logistic EuroScore ≥ 15 or STS-Score ≥ 15 * MR grade ≥ 2, amenable for MitraClip intervention assessed by an experienced interventional cardiologist * Affirmation of in-operability by a "Heart-Team" consisting of either 1 cardiac surgeon and 1 cardiologist or 3 cardiologists Exclusion Criteria: * one essential cardiovascular event in the past 6 weeks; i. e. myocardial infarction, stroke, shock, cardiac decompensation, or the necessity of catecholamine therapy for haemodynamic stabilisation * implantation of a biventricular pacemaker-device for cardiac resynchronisation therapy in the past 3 months * solid tumor with a live expectancy \< 1 year