CompletedPhase 4

Decreasing Postoperative Complications by Goal-Directed Fluid Therapy During Esophageal Resection

Sweden64 participantsStarted 2011-10

Plain-language summary

Surgery for cancer of the esophagus is associated with a high risk of postoperative complications. It has been shown that the risk of postoperative complications can be decreased by optimising the amount and type of infusion fluids given during surgery, steered by measurement of cardiac stroke volume, mostly done with a device called esophageal Doppler. This device can however not be used during this type of surgery. This study wants to test the hypothesis that postoperative complications in patients operated for esophageal cancer can be partially prevented by using a goal directed strategy for the administration of fluids and drugs influencing the heart and vessels, based on measurement of stroke volume by pulse wave analysis (FloTrac).

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Patients scheduled for transthoracic esophageal resection because of malignancy, without colonic interposition who leave informed consent Exclusion Criteria: * ASA 4 or 5 * Atrial Fibrillation * Significant Aortic or Mitral Valve Insufficiency * Preoperative planned extensive monitoring beyond CVP, arterial blood pressure, diuresis, ECG and other standard monitors

What they're measuring

Incidence of complications 5 and 30 days postoperatively

Timeframe: 5 and 30 days postoperatively

Trial details

NCT IDNCT01416077

SponsorUniversity Hospital, Linkoeping

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-10

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