UnknownNot Applicable

Pheno- & Genotyping POF (WHO III)

Netherlands650 participantsStarted 2005-01

Plain-language summary

This study focuses on the phenotyping and genotyping of women with hypergonadotropic ovarian dysfunction (WHO III status).

Who can participate

Age range

12 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * POF; defined as secondary amenorrhea before 40 years of age and basal FSH \> 40 IU/L * Incipient ovarian failure; defined as normo-ovulatory cycles, raised basal FSH \> 12 IU/L * Poor response patients; defined as less than 4 oocytes retrieved or cancellation in case of absent follicle growth after ovarian hyperstimulation with 300 IU gonadotropins or cancellation in case of absent follicle growth * Women with early menopause (between 40-45 years) * Hypergonadotropic primary amenorrhea Exclusion Criteria: * Primary amenorrhea with early development disorders causing absence of ovaries and Swyer syndrome (XY)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

Trial details

NCT IDNCT01411644

SponsorUMC Utrecht

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-06

Contact for this trial

F. Janse, MD

+31 88 75 55555 f.janse@umcutrecht.nl

View on ClinicalTrials.gov More Premature Ovarian Failure (POF) trials