This study focuses on the phenotyping and genotyping of women with hypergonadotropic ovarian dysfunction (WHO III status).
Who can participate
Age range12 Years
SexFEMALE
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Inclusion Criteria:
* POF; defined as secondary amenorrhea before 40 years of age and basal FSH \> 40 IU/L
* Incipient ovarian failure; defined as normo-ovulatory cycles, raised basal FSH \> 12 IU/L
* Poor response patients; defined as less than 4 oocytes retrieved or cancellation in case of absent follicle growth after ovarian hyperstimulation with 300 IU gonadotropins or cancellation in case of absent follicle growth
* Women with early menopause (between 40-45 years)
* Hypergonadotropic primary amenorrhea
Exclusion Criteria:
* Primary amenorrhea with early development disorders causing absence of ovaries and Swyer syndrome (XY)