Active — Not RecruitingNot Applicable

Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome

France47 participantsStarted 2011-01

Plain-language summary

Ovarian insufficiency is common in Turner syndrome related to premature and rapid follicular apoptosis and spontaneous pregnancies are rare in this population. Ovarian cryopreservation has been used in an effort to preserve fertility in patients undergoing treatments which lead to premature and severe ovarian insufficiency. This study aims to assess the relevance of ovarian tissue cryopreservation in girls with Turner syndrome. Based on ovarian follicular density as primary outcome and karyotypic, clinical and hormonal markers as secondary outcomes, analysis of the study will allow to select the patients to whom the procedure would benefit the most.

Who can participate

Age range1 Year – 25 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria : * girls aged from 1 to 25 years included, * with Turner syndrome or mosaic * patients aged more than 18 will only have ovarian insufficiency dated less than 5 years * without any severe disease, particularly of cardiovascular type * whose agreement to participate to the study has been signed by the parents * whose agreement to participate to the study has been signed by majority age patient Exclusion criteria : * girls aged less than one year and over 25 years old * if any surgery would be contra-indicated * ovary alone presence * Well-known infection by HIV, and/or HBV, and/or HCV and/or syphilis TPHA VDRL * No social coverage affiliate

What they're measuring

the ovarian follicular density

Timeframe: at the time of the ovariectomy

Trial details

NCT IDNCT01410045

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-01-16

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