Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary Percutaneous Coronary In… (NCT01408927) | Clinical Trial Compass
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Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary Percutaneous Coronary Intervention or Coronary Artery Bypass Graft Population
United States1,000 participantsStarted 2008-10
Plain-language summary
The primary objective of this prospective clinical registry is to determine the prevalence and level of thienopyridine resistance seen in a population undergoing contemporary percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG).
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Patient \>18 years old.
✓. PCI group only: Patient scheduled to undergo cardiac catheterization or underwent percutaneous coronary intervention (PCI), during hospital stay.
✓. CABG group only: Patient is scheduled to undergo, or has underwent, coronary artery bypass surgery with at least one saphenous vein graft.
✓. Treated with a loading dose of clopidogrel or prasugrel at least 6 hours prior to the blood draw, or on a maintenance dose of clopidogrel or prasugrel for a minimum of 5 days.
✓. Genetic testing subgroup only: Patient has undergone PCI (only), and has been treated with a thienopyridine as in 4.
Exclusion criteria
✕. Known allergies to aspirin, clopidogrel, or prasugrel;
✕. Use of a glycoprotein (GP) IIb/IIIa within 8 hours of the blood draw;
✕. Patient known to be pregnant or lactating;
✕. Patient with known history of bleeding diathesis or currently active bleeding;
✕. Platelet count \<100,000/mm the day of the blood draw;
✕. Hematocrit \<25% the day of the blood draw;
✕. On warfarin therapy at the time of the blood draw;
✕
What they're measuring
1
The prevalence and degree of thienopyridine resistance
Timeframe: Duration of hospital stay; average hospital stay of less than 48 hours