Etoposide, Filgrastim, and Plerixafor in Improving Stem Cell Mobilization in Treating Patients Wi… (NCT01408043) | Clinical Trial Compass
TerminatedNot Applicable
Etoposide, Filgrastim, and Plerixafor in Improving Stem Cell Mobilization in Treating Patients With Non-Hodgkin Lymphoma
Stopped: Slow Accrual
United States25 participantsStarted 2011-10
Plain-language summary
This clinical trial studies etoposide, filgrastim and plerixafor in improving stem cell mobilization in patients with non-Hodgkin lymphoma. Giving colony-stimulating factors, such as filgrastim, and plerixafor and etoposide together helps stem cells move from the patient's bone marrow to the blood so they can be collected and stored.
Who can participate
Age range
18 Years – 78 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Have biopsy-confirmed non-Hodgkin lymphoma, of any type
* Must be eligible for autologous transplantation according to institutional guidelines
* Eastern Cooperative Oncology Group performance status of 0 or 1
* Karnofsky performance status of 70 to 100
* Negative for human immunodeficiency virus (HIV)
* prior to the start of mobilization, subjects must have:
* Absolute neutrophil count of \>= 1.2 x 10\^9/L
* Platelet count of \>= 100 x 10\^9/L
* Creatinine clearance \>= 30 mL/minute
* All patients must be able to comprehend and sign informed consent
* If childbearing potential must either agree to complete abstinence from heterosexual intercourse or effective means of contraception during stem cell mobilization and for at least 3 months following last plerixafor dose; female patients will undergo pregnancy test prior to stem cell mobilization therapy
Exclusion Criteria:
* Have had previous transplants and/or prior mobilization attempts
* Have evidence of progressive non-Hodgkin lymphoma
* Have evidence of bone marrow involvement of lymphoma at time of transplant staging
* Had evidence of active central nervous system (CNS) involvement
* Have had previous radiation of the pelvic area
* Have had prior radioimmunotherapy
* Have received experimental therapy within 2 weeks of enrollment
* Be currently enrolled in another investigational protocol
* Have prior history of other malignancies, excluding basal cell carcinoma or squamous cell carcinoma o…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Collection Using Plerixafor, Etoposide, and Filgrastim