High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spin… (NCT01407705) | Clinical Trial Compass
CompletedNot Applicable
High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spinal Cord Injury (SCI)
United States31 participantsStarted 2007-05
Plain-language summary
The investigators propose a prospective study, designed to analyze the efficacy of High-Resolution Diffusion Tensor Imaging for accurately sensing white matter tracts in subjects with spinal cord injury. Study subjects will not be randomized, as treatment will follow the doctor's "standard of care." Patients will be selected and offered enrollment based upon the clinical diagnosis of spinal cord injury, either due to degenerative disease or trauma. Enrollment will be based on the chronology of patient presentation.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion Criteria:
* For inclusion to the Cervical Spinal Cord (CSM)
* Clinical and Radiographic evidence of cervical spondylotic myelopathy
* 18 to 80 years of age
* Safe and stable clinical scenario to undergo imaging
* Awake, alert patient able to cooperate with physical examination
* Give written informed consent prior to any testing under this protocol
For inclusion to the Control Group, subject must have:
* No diagnosis of cervical degenerative or traumatic disease
* 30 to 80 years of age
* Ability of volunteers to tolerate 1 hr examination
For inclusion to the Degenerative Disease Group, subject must:
* Have signs or symptoms consistent with spinal cord injury.
* Be diagnosed with cervical spondylosis (degenerative disease).
For inclusion to the Traumatic Group, subject must have:
• A spinal cord injury associated with a traumatic event.
Exclusion Criteria:
* For exclusion to the Cervical Spinal Cord (CSM):
* Unsafe or unstable clinical scenario
* Prior cervical spine surgery
* History of neurological disease (stroke, multiple sclerosis, peripheral neuropathy, or other neurodegenerative conditions)
* Inability to comply with physical examination
* Contraindications to MRI imaging (metal debris, cardiac pacemaker, etc..)
* Pregnant women
For exclusion to the other groups:
* Inability to comply with physical examination
* Contraindications to MRI imaging (metal debris, cardiac pacemaker, etc..)
* Pregnant women