Safety & Efficacy WC3011 (Estradiol Vaginal Cream) in the Treatment of Vulvovaginal Atrophy in Postmenopausal Women

Inclusion Criteria: * Postmenopausal females ≥35 years with either or both ovaries removed or naturally menopausal with moderate to severe vaginal dryness Exclusion Criteria: * Hypersensitivity to estrogen and/or progestin therapy * Known or suspected premalignant or malignant disease (except successfully treated skin cancers) * Manifestation of or treatment for significant cardiovascular disease, congestive heart failure, stroke or ischemic attacks * Insulin-dependent diabetes mellitus * Increased frequency or severity of headaches while on hormone or estrogen therapy * Drug or alcohol addiction within last 2 years * Participation in a clinical trial within 30 days * Smoking ≥ 15 cigarettes daily * Uncontrolled hypertension - systolic blood pressure (BP) ≥ 160 mmHg or diastolic BP ≥ 95 mmHg