CompletedNot Applicable

Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary

United States359 participantsStarted 2009-05

Plain-language summary

The Multi-Ethnic Study of Atherosclerosis (MESA) - Chronic Obstructive Pulmonary Disease (COPD) Study aims to characterize the pulmonary vascular changes and their biology in early COPD using imaging, gene expression profiling and peripheral cellular measures.

Who can participate

Age range50 Years – 79 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age 50-79 years at time of enrollment * ever smokers (10 or more pack-years) * participation in MESA or EMCAP studies Exclusion Criteria: * clinical cardiovascular disease (left congestive heart failure (CHF), valve disease, coronary artery disease (CAD), stroke, or congenital heart disease), * asthma, pulmonary embolism or lung disease other than COPD, * weight \> 300 lbs, * chronic renal insufficiency (\[estimated glomerular filtration rate (eGFR)\] \< 45 mL/min/1.73 m2), * atrial fibrillation, and * contraindications to magnetic resonance imagine (MRI), gadolinium, albuterol or spirometry testing.

What they're measuring

Change in cardiac structure and pulmonary vascular structure and function

Timeframe: Up to 2 years from start of study

Trial details

NCT IDNCT01397721

SponsorColumbia University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-04-30

View on ClinicalTrials.gov More Chronic Obstructive Pulmonary Disease trials