CompletedNot Applicable

Cell Samples From Patients With Leukemia

10 participantsStarted 2011-07

Plain-language summary

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about cancer and the development of drug resistance in patients. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial is studying samples from patients with leukemia.

Who can participate

Age range30 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

DISEASE CHARACTERISTICS: * Samples of blood and tissue cells from patients diagnosed with myeloid disease including the following subtypes: * Chronic phase chronic myeloid leukemia (CML), to complement initial studies in the K562 CML cell line * Acute promyelocytic leukemia (APL), to complement initial studies in the NB4 APL cell line * Acute myeloid leukemia (AML) expressing the t(8;21)(q22;q22) translocation, which occurs in approximately 12% of pediatric AML and is associated with good prognosis * AML expressing 5q- or monosomy 7, associated with a poor prognosis * AML expressing the fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD), associated with a poor prognosis PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

What they're measuring

Primary human leukemia samples capable to survive and proliferate in the zebrafish embryo

In vivo confirmation of anti-proliferative or toxic effects of known chemotherapeutic agents on the transplanted cells

Effects of novel anticancer drugs and/or their combinations on individual samples

Trial details

NCT IDNCT01395628

SponsorChildren's Oncology Group

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2016-05

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