RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in blood and tissue samples from patients with newly diagnosed neuroblastoma.
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Association of high expression of NPY and its Y2/Y5 Rs in NBs with poor outcome of the disease, advanced stage, increased vascularization and other unfavorable prognostic factors, such as TrkB expression and MYCN amplification
BDNF/TrkB and TrkAIII up-regulate expression of NPY and its Rs
NPY upregulates expression of the identified proteins in NB and their Rs in endothelial cells (ECs)
Interaction between Y2 and Y5 receptors in NB and ECs sensitize them to NPY and amplify NPY-induced proliferation
Blocking the NPY-Y2/Y5 pathway reduces NB growth and tumor vascularization