Strategies for Enhancing Mucosal Immunity to Influenza Vaccine

Inclusion Criteria: * Healthy men and women ages 18-50 years * Non-smokers (defined as no tobacco use within the last 12 months and less than 10 pack-year lifetime tobacco use) * Willing and able to provide written informed consent * Able to speak and understand English * Women of childbearing potential must have a negative serum pregnancy test. Exclusion Criteria: * Influenza vaccination within 6 months prior to screening date * Symptoms of respiratory infection during the 14 days prior to screening * Temperature \>38.3o C during the period spanning 72 hours prior to screening and the time of immunization. * History of allergy to egg, influenza vaccine or vaccine ingredients * History of Guillain-Barre syndrome * History of Bell's palsy * Tonsillectomy, adenoidectomy or prior surgery to the paranasal sinus cavity. * Physician diagnosis of or personal history of allergic or chronic rhinitis * Physician diagnosis of or personal history of asthma * Acute sinusitis within 30 days prior to screening * Use of antibiotics within 14 days prior to screening * Requirement for use of nasal corticosteroids for the period beginning 30 days prior to screening through final study visit * Requirement for use of antihistamines (systemic, intranasal or intraocular) for the period beginning 72 hours prior to screening through final study visit * Use of immunomodulating drugs or systemic corticosteroids within 6 months prior to screening (includes but is not limited to azathioprine, methotre…