CompletedPhase 4

Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2

Argentina, Australia, Brazil250 participantsStarted 2011-12

Plain-language summary

Objectives: The overall objective is to monitor efficacy of mebendazole (MBZ) against Soil-Transmitted Helminths (STH). The primary objective is: (1) to monitor the efficacy a single dose 500 mg of mebendazole (MBZ) against Soil-Transmitted Helminths (STH) infections by means of Faecal Egg Count Reduction (FECR) and Cure Rate (CR). The secondary objectives are: 1. to assess the occurrence of Necator americanus and Ancylostoma duodenal. 2. to assess the occurrence of β-tubulin mutations related to resistance before and after drug administration. 3. to evaluate the role of dogs and pigs as reservoir for zoonotic transmission.

Who can participate

Age range4 Years – 18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion Criteria: * Subjects who are unable to provide a stool sample at follow-up * Subjects who are experiencing a severe concurrent medical condition * Subjects with diarrhea at first sampling

What they're measuring

Reduction of fecal egg counts at 14 days post-intervention.

Timeframe: At 14 days post-intervention.

Trial details

NCT IDNCT01379326

SponsorUniversity Ghent

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-12

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