CompletedNot Applicable

Multimodal MRI-guided rTMS to Treat Refractory Hallucinations

France85 participantsStarted 2010-11-15

Plain-language summary

* The efficacy of neuro-navigated rTMS for patients with schizophrenia suffering from drug-resistant multisensory hallucinations will be tested by the implementation of a double-blind randomized controlled trial (RCT) * This study will use a combination of different MRI modalities (fMRI and DTI) to define with precision rTMS brain-targets in the case of multisensory hallucinations * The investigators anticipate that multimodal MRI-guided rTMS will allow a significant improvement in the efficacy of neuromodulation treatment of refractory hallucinations

Who can participate

Age range13 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Right-handed Female/Male, \[13-60 y.o.\], * Schizophrenia (DSM-IV-TR diagnosis), * Drug-resistant hallucinations (Kinon \& Kane criteria, 1993), * Unmodified antipsychotic dosage during the 30 days preceding rMTS, * No anticonvulsive medication, * No neurological disorder, no addictive behavior, * Matched for sex, age and PANSS scores, * Consent to participate to the study, Exclusion Criteria: * Pregnancy * Contraindication to MRI scan * Contraindication to rTMS treatment * Claustrophobia * No social insurance

What they're measuring

Severity and Frequency of Hallucinations

Timeframe: Assessed at baseline (t0) and longitudinally after the 10 rTMS sessions during the following month (D+15, M+1, M+3, M+6, M+12)

Trial details

NCT IDNCT01373866

SponsorUniversity Hospital, Lille

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-02-11

View on ClinicalTrials.gov More Hallucinations trials