Resveratrol in Postmenopausal Women With High Body Mass Index

Inclusion Criteria: * Healthy postmenopausal women with a body mass index (BMI) of 25 kg/m\^2 or greater * Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1; Karnofsky 70% or above * Leukocytes \>= 3,000/uL * Absolute neutrophil count (ANC) \>= 1,500/uL * Platelets \>= 100,000/uL * Total bilirubin =\< 2.0 mg/dL * Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\< 1.5 times upper limit of normal (ULN) * Creatinine =\< 1.0 times ULN * Ability and willingness to limit resveratrol-containing foods to no more than one serving each per day for about 14 weeks * Negative mammogram or negative workup of mammographic findings within prior 12 months prior to enrollment for women \>= 50 years of age * Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: * Have had invasive cancer(s) within the past 5 years except non-melanoma skin cancer * Within 3 months of or concurrent usage of any other investigational agents * History of allergic reactions attributed to resveratrol * Unwilling or unable to refrain from taking herbal medicines and dietary supplements * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Within 3 months of or concurrent estrogen or progesterone replacement thera…