Effect of Bone on Vibration-Induced Muscle Electrical Activity (NCT01367041) | Clinical Trial Compass
CompletedNot Applicable
Effect of Bone on Vibration-Induced Muscle Electrical Activity
Turkey (Türkiye)80 participantsStarted 2011-04
Plain-language summary
The aim of this study is to investigate effects of femur exposed to vibration on the rest muscle electrical activity of hip adductors in cases with postmenopausal osteoporosis.
Among patients who will be admitted to the investigators clinic for out-patients and whose bone densitometric measurement will be made with a prediagnosis postmenopausal osteoporosis, a total of 80 voluntaries \[40 having postmenopausal osteoporosis (femur neck or total hip T score \< -2.0) and 40 Controls (Hip and lumbar bone mineral density normal)\] are planned to include in this study.
After the left hip bone mineral density (BMD) and BMC is measured in all cases, whole body vibration will be applied in PMO groups and Controls. The rest muscle electrical activity of left hip muscles will be evaluated at pre-treatment, post-treatment and, during treatment in patients with PMO and then their data will be compared with Controls data.
Plasma sclerostin level will be measured before and 10th minute after vibration.
Cases will stand on vibration plate. WBV will be applied at a frequency of 40 Hz and amplitude of 2 mm for 30 + 30 seconds. WBV will be applied one session only. The left hip BMD and BMC will be evaluated by bone densitometer (Norland).
The rest muscle electrical activity of hip adductor muscles at rest will be measured by PowerLab (data acquisition system, ADInstruments, Australia) device.
This project is planed to be completed in 3 months.
Who can participate
Age range
45 Years – 65 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* postmenopausal women with osteoporosis(femur neck or total hip T score\<-2) or postmenopausal women without osteoporosis (normal femur and lumbar bone mineral density)
* women with ages varying between 45 and 65 years
* right handed women
Exclusion Criteria:
* secondary osteoporosis, fracture history
* early menopause
* osteopenia (-2 \< femur neck or total hip T score \< 1)
* neuropathy (central or peripheral)
* muscle, tendon, joint, vascular, dermatologic disease in lower extremity
* postural abnormality (scoliosis, kyphosis,short leg etc)
* systemic diseases (severe hypertension, coronary heart disease, etc)
* endocrine-metabolic bone diseases\[paget, osteomalacia\]
* medication that could affect the musculoskeletal system
* obesity (BMI \>30 kg/m2 or body weight\>80kg)
* professional sportswoman
* female doing regular sports activities
* non-cooperative subject
* vertigo
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.