Daily IL-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease

Inclusion Criteria: * Recipient of allogeneic stem cell transplantation with myeloablative or non-myeloablative conditioning regimens * Steroid refractory cGVHD with systemic therapy onset within the prior 6 months * No more than 2 prior lines of cGVHD therapy * Estimated life expectancy \> 3 months * Adequate organ function Exclusion Criteria: * Ongoing prednisone requirement \> 1 mg/kg/day (or equivalent) * Concurrent use of calcineurin-inhibitors plus sirolimus * History of thrombotic microangiopathy, hemolytic-uremic syndrome or thrombotic thrombocytopenic purpura * Active malignant relapse * Active uncontrolled infection * Uncontrolled cardiac angina or symptomatic congestive heart failure * Organ transplant (allograft) recipient * HIV-positive on combination antiretroviral therapy * Active hepatitis B or C * Pregnant or breast-feeding