CompletedNot Applicable

Unrelated Donor Stem Cell Transplantation

United States64 participantsStarted 2005-03

Plain-language summary

The purpose of this study is to provide an opportunity for patients with malignancies or bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries.

Who can participate

Age range18 Years – 69 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * \> 18 years of Age * \< 70 years * ECOG performance status 0, 1 or 2 * Left Ventricular Ejection Fraction \> 30% * Creatinine clearance \> 40ml/min * Transaminases \< 2X normal * Total bilirubin \< 2X normal * HIV seronegativity * Weight \< 70kg for cord blood transplantation * Ability to cover the cost of the transplant, necessary medications, and transportation/housing. * Caregiver must be available while outpatient Exclusion Criteria: * Greater than one antigen mismatch at HLA-A, B, C or DR plus one allele mismatch at HLA-A, B, C or DR

What they're measuring

Bone Marrow and Peripheral Blood Chimerism

Timeframe: 30 days post-transplant

Bone Marrow and Peripheral Blood Chimerism

Timeframe: 100 days post-transplant

Bone Marrow and Peripheral Blood Chimerism

Timeframe: 365 days post-transplant

Trial details

NCT IDNCT01364363

SponsorScripps Health

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-07

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