CompletedNot Applicable

National Marrow Donor Program Long-Term Donor Follow-Up

United States21,974 participantsStarted 2010-10

Plain-language summary

This is an observational study of unstimulated bone marrow (BM) and filgrastim-mobilized peripheral blood stem cell (PBSC) donors. The primary goal is to evaluate the hypothesis that the incidence of targeted malignant, thrombotic and autoimmune disorders after unrelated hematopoietic stem cell donation are similar between unstimulated BM and filgrastim-mobilized PBSC donors.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion criteria

✓. Unrelated donor who donated either unstimulated BM or filgrastim-mobilized PBSC between July 1, 1999 and approximately five years post study activation.
✓. Unrelated donor who received at least one injection of filgrastim or more, but did not donate filgrastim-mobilized PBSC between July 1, 1999 and approximately five years post study activation.
✓. Donation was managed by a U.S. NMDP donor center.
✓. Signed informed consent for participation in this long-term donor follow-up study. Concurrent enrollment on other studies is permitted.

Exclusion criteria

✕. Unrelated donor who donated filgrastim-mobilized bone marrow.
✕. Donation was managed by a non-U.S. donor center.
✕. Donor is unable to verbally communicate in any of the following languages: English, Spanish, Mandarin Chinese, Cantonese Chinese, Vietnamese, Korean, or Portuguese.

What they're measuring

Incidence of malignant myeloid hematologic disorders

Timeframe: Post HSCT donation

Trial details

NCT IDNCT01362179

SponsorCenter for International Blood and Marrow Transplant Research

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2020-09-30

View on ClinicalTrials.gov More Hematologic Neoplasms trials