Active — Not RecruitingNot Applicable

Proton Radiation Therapy for Gliomas

United States63 participantsStarted 2011-05

Plain-language summary

In this research study the investigators are looking at a type of radiation called proton radiation. Proton radiation has been shown to deliver virtually no radiation beyond the area of the tumor, sparing surrounding normal tissue from exposure. This may reduce side effects that patients would normally experience with conventional radiation therapy. In this research study the investigators are looking to determine if proton radiation with a reduced field size will be as effective in controlling tumor growth as photon therapy, while reducing the treatment-related side effects observed in patients with brain tumors.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Histologically confirmed low-grade gliomas OR Grade III anaplastic glioma with either or both IDH1 mutation or 1p/19q codeletion * Subject must be indicated for radiation therapy * Life expectancy greater than 5 years * Willing to participate in rigorous neurocognitive evaluations at baseline and serially following treatment * Able to speak and comprehend English * Recovered from adverse events due to agents administered more than 4 weeks before entering study * Able to undergo MRI scans Exclusion Criteria: * Prior cranial radiation therapy * Chemotherapy within 4 weeks prior to entering study * Pregnant or breastfeeding * Known brain metastases * Baseline neurocognitive or emotional disorders * Uncontrolled intercurrent illness * History of a different malignancy unless disease-free for at least 5 years * HIV positive on antiretroviral therapy

What they're measuring

Efficacy

Timeframe: 7 years

Trial details

NCT IDNCT01358058

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-05