A Research Study of Bone Marrow Transplantation From Unrelated or Partially Matched Related Donors

Exclusion criteria

• . Patients with related donors who have a combination of Performance status of \< 70% (TJU Karnofsky) and an HCT-CI of 4 points or more. Patients with unrelated donors with a combination of Performance status of \< 80% (TJU Karnofsky) and an HCT-CI of 4 points or more.
• . Patients with active involvement of the central nervous system with malignancy. Patients with a disease with potential for CNS involvement should have documentation of the lack of CNS involvement via lumbar puncture or similar procedure performed within two months of admission or as per TJU standard practice guidelines.
• . Patients with a psychiatric disorder that would preclude patients from complying with the protocol even with a caregiver. Patients with a lack of social support that would interfere with the ability to receive appropriate medical care will also be excluded.
• . Pregnancy
• . Patients with life expectancy of \< 6 months for reasons other than their underlying hematological/oncological disorder.
• . Patients who have received alemtuzumab within 8 weeks of the transplant admission, or who have recently received horse or rabbit ant-thymocyte globulin and have an ATG level of \> 2 μg/ml. Patients on systemic corticosteroids at a dose equivalent of prednisone 7.5mg/day or higher.
• . Patients who cannot receive cyclophosphamide.
• . Patients with evidence of another malignancy, exclusive of a skin cancer that requires only local treatment, should not be enrolled on this protocol.