CompletedNot Applicable

Physical Fitness, Cardiovascular and Brain Health

United States41 participantsStarted 2011-03

Plain-language summary

The goal of this study is to determine if aerobic exercise or progressive muscle relaxation is associated with changes in cardiovascular health, brain function, and cognition.

Who can participate

Age range

45 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Sedentary adults Participants will be classified as sedentary if they have not engaged in regular physical exercise for at least one year prior to study enrollment. * Ages 45-65 * Normal blood pressure or Borderline or stage 1 hypertension Borderline hypertension will be defined as systolic blood pressure between 120-139 mmHg and/or diastolic blood pressure between 80-89 mmHg. Stage 1 hypertension will be defined as systolic blood pressure between 140-159 mmHg and/or diastolic blood pressure between 90-99 mmHg. Exclusion Criteria: * Signs or symptoms of chronic heart disease * Smoking (current or within the past 6 months) * Peripheral artery disease (ankle-brachial index\<0.9) * Diabetes (fasting blood glucose\>126 mg/L) * Orthopedic problems that would prohibit participants from participating in exercise. * Axis I psychiatric disorder * Magnetic resonance contraindications * Baseline Intellectual Quotient \< 70 * Below chance performance on the practice items of the cognitive tasks * Evidence of large vessel stroke on magnetic resonance imaging

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Percent signal change in Blood oxygen level-dependent (BOLD) response to a working memory task

Timeframe: change from baseline in blood oxygen level-dependent (BOLD) response to WM task at 14 weeks

N-acetyl aspartate (NAA) concentration

Timeframe: change from baseline in N-acetyl aspartate (NAA) concentration at 14 weeks

Trial details

NCT IDNCT01341145

SponsorUniversity of Texas at Austin

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-04

View on ClinicalTrials.gov More Hypertension trials