Randomized Study of Laser and Balloon Angioplasty Versus Balloon Angioplasty to Treat Peripheral In-stent Restenosis

Inclusion Criteria: * PAD with Rutherford class 1-4 * Resting ABI \<0.9 or abnormal exercise ABI \<0.9 * History of previous femoropopliteal nitinol stenting * Angiographic significant restenosis (\>=50%) * Target lesion length \>=4 cm; no more than 3 cm outside stent at either end * Vessel diameter \>=5 mm and \<=7 mm * At least one widely patent tibial or peroneal artery to the foot Exclusion Criteria: * Patient is pregnant or breast feeding * Evidence of acute limb ischemia * Life expectancy \<12 months * CVA within 60 days of screening * Myocardial infarction within 60 days of procedure * Known allergy to contract media * Known contraindication to aspirin, antiplatelet and anti-coagulation therapies * Uncontrolled hypercoagulability * Present or suspected systemic infection in target limb * Serum creatinine \>= 2.5 mg/dl unless dialysis dependent * Previous treatment to target vessel within 3 months of study procedure * Drug eluting stents or covered stents in target lesion * Ipsilateral and/or contralateral iliac stenosis \>= 50% DS that is not successfully treated prior to index procedure or with final residual stenosis \<= 30% documented by angiography * Planned or predicted cardiovascular surgical or interventional procedures prior to completion of the 30-day follow-up * Identification of any lesion below the target stent in the treated leg \>50% that will require preplanned or predicted treatment within 30 days(prior to the 6 month follow up) * Tibial artery conta…