CompletedNot Applicable

Exercise, Age-Related Memory Decline, And Hippocampal Function

United States233 participantsStarted 2011-06

Plain-language summary

The purpose of this study is to test the hypothesis that aerobic exercise leads increased cerebral blood volume in the dentate gyrus of the hippocampus in a sample of young and older adults.

Who can participate

Age range20 Years – 75 Years

SexALL

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Inclusion criteria

✓. Age 20-75 years
✓. English-speaking
✓. Ambulatory
✓. "Average" fitness as determined by ACSM's Guidelines for Exercise Testing and Prescription (for men, VO2max \< 43 for age 20-39 years, \< 38 for age 40-49 years, \< 35 for age 50-59, \< 31 for age 60-75; for women, \< 36 for age \< 30 years, \< 34 for age 30-39 years, \< 32 for age 40-49 years, \<25 for age 50-59 years, \< 24 for age 60-75 years
✓. BMI \<35

Exclusion criteria

✕. Ischemic changes or abnormal resting cardiogram, abnormal blood pressure responses, or an significant ectopy during aerobic capacity testing
✕. Cardiovascular disease
✕. BMI \> 35
✕. Uncontrolled high blood pressure (systolic blood pressure ≥ 140 mmHg; or diastolic blood pressure ≥ 90mmHg on two measures)
✕. Any condition for which aerobic training is counter-indicated, including persons with evidence or history of medical or orthopedic conditions which might make participation problematic.
✕. Current or recent (evidence of disease x 5 years) non-skin neoplastic disease or melanoma. Prostatic carcinoma will not be grounds for exclusion.
✕. Active hepatic disease (not a history of hepatitis) or primary renal disease requiring dialysis, primary untreated endocrine diseases, e.g., Cushing's disease or primary hypothalamic failure or insulin dependent diabetes (Type I or II). Welltreated hypothyroidism will not be excluded.
✕. History of chemotherapy

What they're measuring

dentate gyrus cerebral blood volume

Timeframe: change from before (pre) to after (post) 12 weeks of training

Trial details

NCT IDNCT01329653

SponsorNew York State Psychiatric Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12-31

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