UnknownNot Applicable

DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone)

Israel150 participantsStarted 2011-09

Plain-language summary

Silicosis is well-known occupational disease caused by free crystalline silica (silicon dioxide) and is marked by inflammation and pulmonary fibrosis. There are cumulative evidences that exposure to Caesar stone (quartz surface products that manufactured from up to 93% quartz, polymer resins and pigments) is particularly dangerous to exposed workers. Goals: To examine correlation between disease and exposure to Caesar stone and genetic differences regarding genes involved in oxidative stress to understand Genetic susceptibility

Who can participate

Age range18 Years – 70 Years

SexMALE

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Inclusion criteria

✓. male
✓. 18-70 years old
✓. At least six months of professional exposure to Caesar stone

Exclusion criteria

✕. Other occupational exposure (welding of any kind)
✕. Chronic Obstructive Pulmonary Disease (COPD), tuberculosis, asthma, autoimmune disease in healthy exposed workers
✕. Interstitial lung disease in exposed workers with clinically approved silicosis

What they're measuring

Evidence of clinically definite silicosis according to American Thoracic Society/European Respiratory Society (ATS/ERS)guidelines

Timeframe: one day

Trial details

NCT IDNCT01329003

SponsorTel-Aviv Sourasky Medical Center

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2013-09

Contact for this trial

Daria Bliznuk, BSc

972-0506353669 dasha_bl@yahoo.com

View on ClinicalTrials.gov More Silicosis trials