Lung HIV Disease in a Large Cohort-Pitt (NCT01326572) | Clinical Trial Compass
CompletedNot Applicable
Lung HIV Disease in a Large Cohort-Pitt
United States189 participantsStarted 2009-01
Plain-language summary
HIV-infected patients have an increased incidence of emphysema compared to non-HIV-infected patients, and it has been hypothesized that this accelerated disease progression is the result of one or more latent infections that amplifies the pulmonary inflammatory response. The investigators will examine the prevalence and progression of emphysema in subjects with and without HIV and determine risk factors for emphysema in this population.
Who can participate
Age range
18 Years – 72 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years old or older
* By participant's report, s/he is:
* HIV positive OR
* HIV negative and at high risk
* Recruited via:
* Pitt Men's Study/MAC
* Women's Interagency Health Study
* Attendee of UPMC HIV/AIDS Program
Exclusion Criteria:
* Acute onset of shortness of breath, cough, fever or heart condition such as tachycardia, angina or arrhythmias
* Pregnancy
* MI, CVA or cardiovascular event within last 3 months
* Eye or abdominal surgery with last 3 months
* Active TB by documentation or self-report
* Weight \> 500 lbs.
* Exposure to \> 10 rads in the previous 12 months (i.e., 2 CT or 4 cardiac cath…or other fluoroscopic exams For bronchoscopy subjects only
* Subjects with an upper or lower respiratory tract infection
* Individuals with a Primary diagnosis of vocal cord dysfunction, or those with significant or uncontrolled systemic diseases will be excluded
* 75 years of age or older
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The investigators will compare emphysema in the HIV+ and HIV- subjects and compare progression over time.