UnknownNot Applicable

Angiogenic Cytokines and Fibrinolytic Activity in Parapneumonic Effusions

Taiwan80 participantsStarted 2008-01

Plain-language summary

Angiogenesis is a key process in the formation of exudative pleural effusions. Fluid loculation is common in parapneumonic effusion and is associated with depressed pleural fibrinolytic activity and poor clinical outcome. However, the relationship between angiogenic cytokines and fibrinolytic activity in the pleural space remains unclear. The researchers's hypothesis is that the levels of angiogenic cytokines were increased and associated with decreased fibrinolytic activity in parapneumonic effusions which may contribute to fibrin deposition and fluid loculation in the pleural space.

Who can participate

Age range18 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with pleural effusions of unknown causes admitted to Taipei Medical University Hospital were included if parapneumonic effusion was diagnosed as one associated with pneumonia according to the criteria of the American Thoracic Society (ie, patients with newly acquired respiratory symptoms, fever, and abnormal breath sounds, plus a new lung infiltrate seen on a chest radiograph). Exclusion Criteria: * History of chest trauma or invasive procedures directed into the pleural cavity; bleeding disorder or anticoagulant therapy * Use of streptokinase in the previous 2 years; and likely survival less than 6 months.

What they're measuring

Response to treatment including improvement in vital signs and chest radiography

Timeframe: 5 days after treatment within admission

Trial details

NCT IDNCT01325454

SponsorTaipei Medical University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2011-06

View on ClinicalTrials.gov More Pleural Effusion trials