Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer

Inclusion Criteria: * The study candidate must have sufficient Formalin Fixed Paraffin Embedded (FFPE)Specimens (lymph node or tumor) for DNA extraction available for study SNP assessment * Patients over the age of 21 with a histologically confirmed diagnosis of cancer who have received nitrogen containing bisphosphonate therapy for metastatic bone disease. * FFPE tissues are to have been removed for clinical indication and sufficience study volume of specimen must be available in an established tissue repository. * \- Study FFPE tissues include: * formalin fixed paraffin embedded leukocytes from lymph nodes with or without involvement by tumor AND/OR * formalin fixed paraffin embedded tumor tissue (tumor block without invasive cancer is acceptable if the specimen is believed to be sufficiently cellular (breast tissue or noninvasive cancer) to yield adequate DNA) * Medical records available for data abstraction Exclusion Criteria: * Insufficient specimen available to perform the assays proposed for specimen DNA analysis * No accessable medical records