CompletedNot Applicable

Imaging Study of the White Matter Lesions in Children With Metachromatic Leucodystrophy

France29 participantsStarted 2010-11

Plain-language summary

High-field MRI and diffusion tensor imaging with 3D reconstruction of the myelin tracks, in combination with multivoxel proton spectroscopy, will allow to precise more accurately the evolution of the white matter lesions in patients affected with Metachromatic Leukodystrophy (particularly in the initial phase of the disease). This will increase the knowledge of the disease and provide new indicators for the selection and evaluation of patients eligible for new therapeutic approaches.

Who can participate

Age range1 Year – 6 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria (patients): * Children with proven metachromatic leukodystrophy (MLD) with decreased activity of arylsulfatase A enzyme in leukocytes and abnormal excretion of urinary sulfatides * Age ≥ 1 year and ≤ 6 years * Recently diagnosed (within \< 18 months) Inclusion Criteria (control): * Children with partial cryptogenic epilepsy or with a suspected brain lesion on conventional MRI, who should have high-field MRI to detect structural abnormalities that could benefit from surgical resection * Age ≥ 1 year and ≤ 6 years Exclusion Criteria: * Evolutive heart, pulmonary, renal or gastrointestinal disease * Contra-indication to sedation * Contra-indication to MRI (implanted magnetic material)

What they're measuring

Assess the natural history of the white matter and cortex lesions in MLD using diffusion tensor imaging (DTI)and relaxometry/ high field MRI.

Timeframe: At inclusion (T0) and 12 months for control. At T0 then at 6 months for patients

Trial details

NCT IDNCT01325025

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-03