A Multicenter Study of NB-001 in the Treatment of Recurrent Herpes Labialis (SHaRCS)

Inclusion Criteria: * A healthy man or woman 18 years of age or older. Women who are pregnant, lactating or may become pregnant may (at the investigator's discretion) be included in the study. * Have recurrent herpes labialis as defined by a history of three (3) or more cold sore recurrences on the lips and/or skin surrounding the lips in the previous 12 months; * Have the majority of their cold sore recurrences preceded by a well defined history of prodromal symptoms. Exclusion Criteria: * Subjects with severe chronic illness * Received (within the last 6 months) or receiving chemotherapy; * Significant skin disease on the face * Previously received herpes vaccine; * Active alcohol or drug abuse; * Prior randomization into any NanoBio study; * Known allergies to topical creams, ointments or other topical medications.