UnknownPhase 1

Use of Granulocyte Colony-stimulating Factor for the Treatment of Recurrent Implantation Failure in IVF Patients

Israel20 participantsStarted 2011-06

Plain-language summary

The investigators use granulocyte colony-stimulating factor (GCSF) for the treatment of recurrent implantation failure in IVF patient with cause unknown or due to thin endometrium. Several studies showed that GCSF improves embryo development and implantation and increase pregnancy rate.

Who can participate

Age range20 Years – 45 Years

SexFEMALE

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Inclusion criteria

✓. women after 5 failures in IVF cycles with cause unknown.
✓. women after 5 failures in IVF due to thin endometrium (\<6 mm) and unresponsive to estrogen supplements.

Exclusion criteria

✕. history of hematology disease
✕. allergy to GCSF
✕. neutrophilia
✕. severe lower back pain
✕. liver dysfunction
✕. hyperuricemia
✕. a recent febrile disease or pneumonia
✕. rheumatoid arthritis 9. sickle cell disease-

What they're measuring

pregnancy rate

Timeframe: 18 months

Trial details

NCT IDNCT01315470

SponsorHadassah Medical Organization

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2013-01

Contact for this trial

einat zivi, MD

0508573943 zivi_e@hotmail.com

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