Advanced Imaging for Glaucoma Study (NCT01314326) | Clinical Trial Compass
CompletedNot Applicable
Advanced Imaging for Glaucoma Study
United States832 participantsStarted 2003-09
Plain-language summary
The specific aims of the clinical studies are to:
1. Predict the development of glaucomatous visual field (VF) abnormality in glaucoma suspects and pre-perimetric glaucoma patients based on anatomic abnormalities detected by advanced imaging.
2. Predict the development of glaucomatous VF abnormality in glaucoma suspects and pre-perimetric glaucoma patients based on anatomic changes detected between successive advanced imaging tests.
3. Determine the sensitivity and specificity of glaucoma diagnosis based on advanced imaging tests.
Who can participate
Age range
40 Years – 79 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for Normal Participants:
* No history of glaucoma, retinal pathology, keratorefractive surgery, or corticosteroid use.
* Normal visual field (VF), intraocular pressure (IOP), optic nerve head and nerve fiber layer.
* Central pachymetry \> 500 μm.
* Open angle.
Inclusion Criteria for Glaucoma Suspects \& Pre-Perimetric Glaucoma Participants:
* Ocular hypertension, defined as IOP ≥ 24 mmHg in one eye and IOP ≥ 22 mmHg in the fellow eye, on or off glaucoma medications.
* Optic nerve head (ONH) or nerve fiber layer (NFL) defect visible on slit-lamp biomicroscopy and stereo color fundus photography as defined for the PG group.
* The fellow eye meeting the eligibility criteria for the PG group.
* GSPPG eyes must not have an abnormal VF as defined for the PG group.
* GSPPG participants having glaucomatous ONH or NFL defect are subclassified as PPG; the remainder are subclassified as GS.
Inclusion Criteria for Perimetric Glaucoma Participants:
* Abnormal VF and
* Glaucomatous ONH of NFL defect.
Exclusion Criteria Common to All Groups:
* Best corrected visual acuity worse than 20/40.
* Age \< 40 or \> 79 years.
* Refractive error \> +3.0D or \< -7.0 D.
* Previous intraocular surgery except for uncomplicated cataract extraction with posterior chamber IOL implantation.
* Diabetic retinopathy or other disease that may cause visual field loss or optic disc abnormalities.
* Inability to clinically view or photograph the optic discs due to media opacity or poorly d…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Developing glaucoma or progression with glaucoma as defined by study criteria