An Efficacy and Safety Study of Periarticular Parecoxib Sodium for Pain Management in Total Knee Arthroplasty

Inclusion Criteria: * Patients with primary knee osteoarthritis on treatment and planned for unilateral total knee arthroplasty and on spinal/general anesthesia * Subjects age more than 50 and less than 85 years * Patients with body weight at least 50 kg and not more than 50%above ideal body weight * Written informed consent obtained from patient or guardian Exclusion Criteria: * Female patients who are attempting to conceive/pregnant * Known allergy or hypersensitivity to cocktail regime or to COX-2 inhibitors * History of bleeding disorders or coagulation defect * Patients with abnormal liver profile * Patients with history of stroke or major neurological defect * Patients with neuropathic pain/sensory disorder * Patients with peptic ulceration or anticoagulant use within 1 month * History of previous major knee surgery/trauma * Patients with renal insufficiency * History of revision total knee arthroplasty * Patients with knee deformity \> 20 degrees * Patients planned for bilateral knee arthroplasty during the same setting * Patients with significant bone loss requiring augmentation * Patients with history of using NSAIDs 24 hours before the surgery