Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia

Inclusion Criteria: * Patients must have one of the following diagnoses and/or treatment plans: * Newly diagnosed de novo AML * First or subsequent relapse of AML * Secondary AML * Treatment with institutional standard AML therapy in those without AML (for example, myelodysplastic syndrome, bone marrow blasts \> 5% or biphenotypia) * Note: Patients with a history of prolonged antifungal therapy (example, relapsed AML) are eligible * Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2 OR a serum creatinine based on age/gender as follows: * =\< 0.4 mg/dL (age 1 month to \< 6 months) * =\< 0.5 mg/dL (age 6 months to \< 1 year) * =\< 0.6 mg/dL (age 1 to \< 2 years) * =\< 0.8 mg/dL (age 2 to \< 6 years) * =\< 1 mg/dL (age 6 to \< 10 years) * =\< 1.2 mg/dL (age 10 to \< 13 years) * =\< 1.4 mg/dL (females age \>= 13 years) * =\< 1.5 mg/dL (males age 13 to \< 16 years) * =\< 1.7 mg/dL (males age \>= 16 years) * Total bilirubin =\< 1.5 x upper limit of normal (ULN) for age AND Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase \[AST\]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) \< 2.5 x ULN for age * All patients and/or their parents or legal guardians must sign a written informed consent Exclusion Criteria: * Patients with the following diagnoses are not eligible: * Acute promyelocytic leukemia (APL) * Down syndrome * Juvenile myelomonocyti…