The Effects of Radiation in Reconstructed Breasts

Inclusion Criteria: * Female patients between 18 and 90 years of age. * Patients with a diagnosis of unilateral breast cancer who elect to undergo bilateral mastectomy with immediate free flap reconstruction. * Patients must also have a locally advanced tumor that requires adjuvant radiation therapy following reconstruction. Exclusion Criteria: * Women who do not undergo immediate, bilateral breast reconstruction using a free flap. * Women who do not require unilateral, adjuvant radiation therapy * Women who are pregnant * Women who have altered renal function, defined as a personal history of diabetic, hypertensive or autoimmune nephropathy and/or on routine preoperative testing are found to have a serum creatinine greater than or equal to 1.3