Trial of Drain Antisepsis After Tissue Expander Breast Reconstruction

Inclusion Criteria: * Females or males age 18-90 able to give informed consent * Undergoing bilateral mastectomy with immediate expander reconstruction or immediate implant reconstruction * May have either malignant or benign breast condition Exclusion Criteria: * Antibiotic use in the fourteen days prior to surgical date * Undergoing unilateral tissue expander reconstruction * Documented allergy to chlorhexidine gluconate * Prior radiation therapy to the breast or chest wall (ie for breast conservation or mantle radiation for Hodgkin's disease) * Documented allergy to all three of the following antibiotics: cephalosporin, trimethoprim/sulfamethoxazole, and levofloxacin * Pregnant women * Vulnerable subjects - prisoners, institutionalized individuals * Non-English speaking patients without adequate interpreter assistance