CompletedPhase 4

Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study)

France400 participantsStarted 2011-01

Plain-language summary

The purpose of this study is to compare the influence of a lung protective ventilation with conventional ventilation on postoperative complications following major abdominal surgery.

Who can participate

Age range40 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Planned intrabdominal surgery * Expected duration ≥ 2 hours * Age ≥ 40 yr (and \<90 yr) * Risk of postoperative pulmonary complications (Arozullah score ≥2) Exclusion Criteria: * Noninvasive ventilation in the last 30 days * Recent history of pneumonia, ALI/ARDS (in the last 30 days) * History of pulmonary resection * History of neuromuscular disease * Patient refusal

What they're measuring

Composite endpoint defined as incidence of major postoperative pulmonary (defined as pneumonia, need for noninvasive ventilation or need for invasive ventilation) and extrapulmonary (SIRS, sepsis and septic shock) complications

Timeframe: during the first seven days after surgery

Trial details

NCT IDNCT01282996

SponsorUniversity Hospital, Clermont-Ferrand

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-08

View on ClinicalTrials.gov More Protective Lung Ventilation Using: trials