CompletedNot Applicable

Study of Sequential Perfusion of Liver Grafts to Prevent Nonanastomotic Biliary Strictures After Liver Transplantation

China141 participantsStarted 2004-07

Plain-language summary

The study was designed to investigate whether, compared with conventional sole perfusion with high-viscosity solution of University of Wisconsin (UW), sequential perfusion of liver grafts with low-viscosity and high-viscosity preservation solutions could further decrease the incidence of nonanastomotic biliary strictures (NAS) after liver transplantation.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age≥18 years * ability to provide written informed consent prior to study entry * receiving a whole liver graft * primary transplantation Exclusion Criteria: * participant in other clinical trials * fulminant liver failure as the cause of transplantation * primary biliary cirrhosis, autoimmune hepatitis or primary sclerosing cholangitis as primary liver disease * retransplantation * non-liver organ(s) failure prior to study entry * donor/recipient ABO-blood-group-incompatibility

What they're measuring

Number of participants with primary non-function (PNF) for safety assessment of sequential perfusion

Timeframe: 1 week

Number of participants with nonanastomotic biliary strictures with a patent hepatic artery

Timeframe: 5 years

Trial details

NCT IDNCT01271179

SponsorShanghai Jiao Tong University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2010-12

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