Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Inclusion Criteria: * Adult male or female (surgically sterile or post-menopausal or confirmed not to be pregnant) * Trauma injury (blunt and/or penetrating) resulting in lactic acidosis due to hemorrhagic shock * Acidosis (blood lactate level ≥ 5 mmol/L; equivalent to 45 mg/dL) arterial or venous Exclusion Criteria: * Massive injury incompatible with life * Normalization of lactate prior to dosing (≤ 2.2 mmol/L) * Patients with evidence of severe traumatic brain injury as defined by ANY one of the following: Known non-survivable head injury or open brain injury; Glasgow Coma Score (GCS) = 3, 4 or 5; Known AIS (head region) ≥ 4 shown by an appropriate imaging methodology; Contemplated CNS surgery; or Abnormal physical exam indicative of severe CNS or any spinal cord injury above T5 level * Cardiac arrest prior to randomization * Age below the legal age for consenting * Estimated time from injury to randomization\> 4 hours * Estimated time from hospital admission to randomization \> 2 hours * Known pregnancy * Use of any oxygen carrier other than RBCs * Known previous participation in this study * Professional or ancillary personnel involved with this study * Known receipt of any investigational drug(s) within 30 days prior to study